The relentless surge of high-profile cyberattacks—from nation-state breaches targeting critical infrastructure to ransomware paralyzing essential services—demands a fundamental reimagining of how we secure our digital world. NosTerra's Information Security Grand Challenge backs visionary entrepreneurs who refuse to accept that cybersecurity must always be reactive, instead investing in founders who are building hardware-rooted solutions and AI-powered defenses that can anticipate and neutralize threats before they materialize. By leveraging breakthrough technologies in physics, optical networking, and embedded security processors, we support entrepreneurs with the tenacity to challenge legacy security paradigms and create end-to-end protection systems that will safeguard people, critical infrastructure, and data for decades.